Floccinaucinihilipilification

By virtue of having one more letter than antidisestablishmentarianism, this is the longest non-technical English word. A mash up of five Latin roots, it refers to the act of describing something as having little or no value. While it made the cut in the Oxford English Dictionary, Merriam-Webster volumes refuse to recognize it, chalking up its existence to little more than linguistic ephemera.

Latin floccus (“a wisp”) +‎ naucum (“a trifle”) +‎ nihilum (“nothing”) +‎ pilus (“a hair”) + English -fication

From Steven Pinker, The language Instinct:

Even more impressive, the output of one morphological rule can
be the input to another, or to itself: one can talk about the unmicro-
waveability of some French fries or a toothbrush-holder fastener box
in which to keep one's toothbrush-holder fasteners. This makes the
number of possible words in a language bigger than immense; like
the number of sentences, it is infinite. Putting aside fanciful coinages
concocted for immortality in Guinness, a candidate for the longest
word to date in English might be floccinaucinihilipilification, defined
in the Oxford English Dictionary as "the categorizing of something as
worthless or trivial." But that is a record meant to be broken:
floccinaucinihilipilificational: pertaining to the categorizing
of something as worthless or trivial
floccinaucinihilipilificationalize: to cause something to pertain
to the categorizing of something as worthless or trivial
floccinaucinihilipilificationalization: the act of causing some-
thing to pertain to the categorizing of something as worth-
less or trivial

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